How to Fix Your Gut & Heal Your Body with Dr. Vincent Pedre

Meet Vincent M. Pedre the Medical Director of Pedre Integrative Health and President of Dr. Pedre Wellness. Dr. Pedre is a Board-Certified Internist and Functional Medicine Certified Practitioner in private practice in New York City since 2004. His philosophy and practices are a blend of both Western and Eastern medical traditions. He is a Clinical Instructor at the Mount Sinai School of Medicine, as well as certified in yoga and Medical Acupuncture.Links for this episode:Fermented-food diet increases microbiome diversity, decreases inflammatory proteins, study findsThe Importance of Food for Endotoxemia and an Inflammatory ResponseGutSmartProtocol.comThe GutSMART QuizInstagram @drpedreEpisode Description00:07:30 - The Gut-Skin Connection, <br />The gut and skin originate from the same cells in embryology, making their connection significant. Patients with skin issues may benefit from a functional medicine approach that considers the connection between gut health and skin issues, like hives, acne, psoriasis, and dermatitis.<br /><br />00:11:45 - Celiac Genetics and Gluten-Free Diets, <br />Celiac genetics are prevalent in people of Irish descent, and eliminating gluten from the diet can alleviate hives and other skin issues. A functional medicine approach can provide a solution for patients who have seen dermatologists without any results.<br /><br />00:13:35 - Good and Bad Bacteria in the Gut, <br />The gut microbiome is a complex ecosystem that includes a set of bad bacteria that serve a purpose and keep the system in balance. Opportunistic bacteria can flourish in environments where the diet is not optimal, leading to gut-centric and non-gut-centric issues.<br /><br />00:16:23 - The Gut Microbiome of Indigenous Tribes, <br />Dr. Pedre discusses the gut microbiome of indigenous tribes and how it differs from Westerners. Indigenous tribes consume a high-fiber diet, and their gut microbiome has adapted to digest difficult-to-digest fibers. <br /><br />00:20:20 - The Importance of Gut Microbiome Adaptation, <br />Dr. Pedre stresses the importance of slowly introducing changes to the gut microbiome. A sudden change can lead to bloating and discomfort. <br /><br />00:25:05 - The Gut-Airway Connection, <br />Dr. Pedre explains how the gut microbiome is connected to upper respiratory infections. Antibiotics can disrupt the gut microbiome and immune system, leading to recurrent infections. Pregnancy can ramp up the immune system, but can also suppress certain parts to protect the baby.<br /><br />00:29:35 - Lipopolysaccharides and Metabolism, <br />Dr. Pedre explains that Lipopolysaccharides (LPs), also known as endotoxins, are released by gram-negative bacteria and can be absorbed into the body. LPs levels increase after meals high in fat, especially saturated and hydrogenated fats. LPs can affect metabolism and insulin sensitivity.<br /><br />00:33:42 - Microbiome and Leaky Gut, <br />Dr. Pedre explains how an unfavorable microbiome and leaky gut can lead to the absorption of lipopolysaccharides and cause many health issues, such as weight gain, muscle aches, fatigue, and depression. Keeping a food, mood and poop journal can help identify patterns and triggers.<br /><br />00:35:34 - Timeline for Food Sensitivities, <br />Dr. Estima and Dr. Pedre discuss the importance of keeping a food journal to identify patterns of food sensitivities. They explain how sensitivities can have a threshold effect, where one exposure may be fine, but a second ex